‘Awkward’ Louisiana Senate race divides Republicans

Burgess Everett
Burgess Everett
Congressional Bureau Chief
Apr 24, 2026, 5:10am EDT
Politics
Sen. Bill Cassidy, R-La.
Annabelle Gordon/Reuters
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Louisiana is home to Mardi Gras, cajun cooking, and Republicans’ most awkward Senate race.

Senate Republicans are torn between one of their own chairman, Bill Cassidy of Louisiana, and President Donald Trump’s pick, Rep. Julia Letlow, in a unique test of an incumbent senator facing the wrath of a president he voted to disqualify from future office in 2021. Sen. Lisa Murkowski, R-Alaska, survived a similar battle in 2022, but there are important differences: Trump is now sitting president; Letlow is a more serious threat than Murkowski’s opponent, Kelly Tshibaka; and Cassidy is not a moderate like Murkowski.

And Republicans are trying to save the Senate majority and Louisiana is a deep-red state that Democrats aren’t even contesting. That’s turned GOP groups’ focus elsewhere, even as Cassidy is nearly universally respected in the Senate Republican Conference as a sober, serious legislator with deep policy knowledge.

“Bill’s a good guy. I like him. How the race shakes out is up to the voters of Louisiana. Obviously, the president has a reason to feel the way he does, and I can understand that too,” said Sen. Bernie Moreno, R-Ohio, a vice-chair at the National Republican Senatorial Committee who is vying to lead the committee next year.

Moreno noted the NRSC has helped Cassidy but said he personally is staying out of it going forward: “It’s always awkward, but ultimately he’s gotta make his case. [Letlow is] gonna make the case, and we’ll see how it shakes out.”

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Letlow isn’t winning over GOP senators to her side yet, though her entry into the race is freezing plenty of politically-active Republicans from siding directly with Cassidy. The May 16 primary among Cassidy, Letlow, and former Rep. John Fleming, R-La., is chaotic and difficult to assess — and likely to go to a runoff between the top two finishers. Polls show no clear-cut favorites even to make the runoff.

Moreno isn’t alone on the sidelines: Sen. John Kennedy, R-La., is officially neutral (though his PAC previously donated to Cassidy) and Moreno’s fellow vice-chair, Sen. Jim Banks, R-Ind., has kept quiet on the race. The same goes for former NRSC chairmen Rick Scott, R-Fla., and Sen. John Cornyn, R-Texas, who has his own tricky primary to contend with.

“I’m gonna leave that between Senator Cassidy and President Trump — well, actually, between Senator Cassidy and the voters in Louisiana. They’re going to have the final say. I’m focused on my race, as you might imagine,” Cornyn said.

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Scott, who endorsed Murkowski in 2022 as NRSC chairman, said that he has “a good relationship with Bill Cassidy” but he “generally” doesn’t get involved in primaries.

The party infrastructure has lent some help to the incumbent GOP senator.

Senate Majority Leader John Thune took part in a political event with Cassidy in January to raise more than $600,000 shortly before Letlow jumped into the race; Thune stands by his endorsement for Cassidy, according to a person familiar with the matter. NRSC Chair Tim Scott, R-S.C., endorsed Cassidy and the group has assisted his campaign.

But the Senate GOP’s top super PAC, the Senate Leadership Fund, is focused on battleground states and has not spent in deep-red Louisiana. (Under different leadership, SLF spent $6 million to help Murkowski in 2022.) Cassidy is listed on their candidates website.

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In an interview, Cassidy said he felt sufficiently supported by the GOP political machine and said he has a “good working relationship” with the NRSC. He declined to say he wants more air support from GOP groups.

“I’d rather not talk about the mechanics of the race,” Cassidy said. “I’m very comfortable with how things are transpiring.”

Still, the dynamics are causing some Republicans to question how much the party will have their backs when they face future primary challenges. One Republican senator acknowledged it’s “awkward, but I still think we can do more. He’s the incumbent. He’s been a valuable member of the conference.”

“Sen. Cassidy is one of the most capable US senators that I’ve had the pleasure of serving with. It is a shame that we can’t get the administration and other people to see that,” said Sen. Thom Tillis, R-N.C., who is retiring at the end of the year and has his own feud with the Trump administration. He said GOP groups are sufficiently helping Cassidy, “but you can never do enough in these races. To me, you’ve always got to protect your incumbents.”

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GOP strategists believe Cassidy’s problem is less about spending and more about his tensions with Trump. His campaign had $7 million on hand and a pro-Cassidy super PAC, the Louisiana Freedom Fund, spent more than $7 million in the first quarter of the year and more still this month.

Trump was angry that Cassidy won his last race as a Trump ally only to vote against him at the 2021 impeachment trial after Jan. 6. That vote is his most obvious challenge with Trump, but Cassidy also has an up-and-down relationship with Health and Human Services Secretary Robert F. Kennedy Jr., after casting a decisive vote for him. He also sought to nudge Trump out of the last presidential race in 2023.

“I can see where President Trump gets so frustrated, he helps a lot of these candidates. … It’s not that he demands loyalty. He also just doesn’t want people to turn on him,” Moreno explained. “When you come here and don’t do what you tell the voters you’d do, I think that’s what angers President Trump.”

At the same time, Cassidy has tried to work with the Trump administration and the president himself and is mostly voting with Trump. Letlow is not handily defeating Cassidy at this point in the race, and pro-Cassidy outside spending — mostly raining down on Letlow — dwarfs his opponents.

“He’s doing a terrific job. I’ve talked to him recently. He’s fully into the race,” said Senate Majority Whip John Barrasso, R-Wyo., said.

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Burgess’s view

We’ve seen races pit Trump against his conservative foes, but this one stands out. Even Trump’s revenge tour against Rep. Thomas Massie, R-Ky., isn’t analogous — because other than that impeachment vote, Cassidy has mostly been a team player for the GOP when it counts.

Party leaders worry more about the majority than a safe seat in Louisiana. Cassidy seems to have anticipated this with his massive war chest and big super PAC allies — but spending isn’t everything. And Republican senators are watching very closely to see if he can pull off a primary win.

After all, if Cassidy can survive, Republicans will know that their voters don’t always blindly follow Trump’s endorsements. If he loses, the political incentive to cross Trump becomes even more of a losing proposition.

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